SR9009 (Stenabolic)

SR9009 (Stenabolic) commonly known as Stenabolic, is a synthetic REV-ERBα/β agonist that has gained attention in preclinical research for its unique ability to modulate metabolism, enhance endurance, and influence circadian rhythms. Unlike traditional anabolic compounds, SR-9009 works by binding to REV-ERB nuclear receptors, which play a crucial role in energy expenditure, mitochondrial function, and sleep-wake cycles.

This compound is classified as an “exercise mimetic”—a substance that mimics the effects of physical exercise—making it a valuable research tool for studying metabolic disorders, obesity, and muscle fatigue resistance.

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Mechanism of Action: How SR-9009 Works

SR-9009’s primary mechanism involves activating REV-ERB proteins, which regulate:
✔ Mitochondrial Biogenesis – Increases energy production in cells.
✔ Lipid Metabolism – Enhances fat oxidation (fat-burning).
✔ Circadian Rhythm – Modulates genes linked to sleep and metabolism.

By stimulating these pathways, SR-9009 has been shown in preclinical studies to:

• Boost endurance (prolonged treadmill runtime in animal models).

• Reduce fat accumulation without dietary changes.

• Improve metabolic rate (increased oxygen consumption).

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Key Research Applications of SR-9009

1. Endurance & Exercise Performance

• Studies suggest SR-9009 enhances stamina by improving mitochondrial efficiency.

• Potential use in fatigue resistance research for athletes and military applications.

2. Fat Loss & Metabolic Syndrome

• Promotes lipid oxidation, making it relevant for obesity and diabetes studies.

• Unlike stimulants, it does not increase heart rate or blood pressure.

3. Circadian Rhythm & Sleep Disorders

• REV-ERB agonists like SR-9009 may help regulate sleep cycles and metabolic health.

• Investigated for shift work disorder and jet lag adaptation.

4. Neuroprotection & Anti-Inflammatory Effects

• Early research indicates potential neuroprotective benefits in neurodegenerative models.

• May reduce chronic inflammation linked to metabolic diseases.

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Pharmacokinetics & Research Considerations

• Short Half-Life (~4 hours) – Requires frequent dosing in studies.

• Bioavailability Challenges – Poor oral absorption; often administered via injection in preclinical models.

• Optimal Research Dosage – Varies by study design (common range: 5-30 mg/kg in animal models).

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SR-9009 vs. Other Metabolic Modulators

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Where to Buy SR-9009 for Research

For laboratories studying metabolic pathways and exercise mimetics, sourcing high-purity SR-9009 is critical. Look for:
✔ Third-party testing (HPLC/MS verification)
✔ Certificate of Analysis (COA) for purity confirmation
✔ Reputable suppliers specializing in research chemicals

Note: SR-9009 is not approved for human consumption and is strictly for scientific investigation.

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Conclusion: The Future of SR-9009 Research

SR-9009 remains a promising compound for studying metabolism, endurance, and circadian biology. Its ability to enhance mitochondrial function without stimulant effects makes it unique among research chemicals. Future studies may explore:

• Combination therapies with other metabolic agents.

• Clinical potential for metabolic and sleep disorders (pending further research).

For scientists and research institutions, SR-9009 offers a valuable tool to investigate energy regulation, fat loss mechanisms, and fatigue resistance.